LUFS stands for the luteinisation of ovulatory follicle without releasing an oocyte. Therefore, it can be considered as a form of anovulation belonging to anovulation functional problems category. Functional problems accounts for up to 15 % cases of anovulation. As it is a disorder united with the start of so called luteal phase, it may be also characterized as luteal phase defect (LPD). It seems that LUFS is related to hormonal imbalance causing the detention of oocyte within the follicle even though the follicle itself transforms under LH (luteinizing hormone) influence into corpus luteum (Pic. 1). The oocyte detention prohibits the conception, yet menstrual cycle is in any other aspect undergoing normally without any side effects.

Regarding the importance of progesterone and its role in the ovulation, it is reasonable to assume that its lowered levels may be responsible for LUF to happen. As no oocyte is released and no conception happens, the uterus soon starts to produce prostaglandin f2α as if regular ovulation would happen and the menstruation cycle begins again without any obvious signs showing that there’s any kind of disturbance in the menstrual cycle. 

LUF is observed in 10% of natural menstrual cycles in fertile women, but in stimulated cycles it is higher. The incidence of LUF has been reported to be 25–43% in infertile women.

Associated diseases 


There are no side complications related with this reproduction disorder except conception is not possible to happen if oocyte is held within the ovary after ovulation reducing the fertility possibilities.

Risk factors 

Several investigations have shown that anti-inflammatory nonsteroidal drugs may be related with higher incidence of LUFS. Hormonal imbalance of gonadotropins (LH and FSH) is another risk factor.

Without a release of an oocyte, it is impossible for a woman to get pregnant in “old fashion” way, meaning that LUFS significantly reduce the fertility potential of a woman. Yet luteinised unruptured follicles syndrome is not affecting every ovulation so it may “just” take significantly longer time to get pregnant. There are various medical/assisted reproduction treatments available for LUFS, so it is no terminal condition which would exclude pregnancy completely.

There’s no clear prevention for LUFS to happen. On the other hand, the quality of alimentation has quite great impact on hormonal balance of the body, including progesterone production. Proper supplementation with fatty acids may help to maintain the progesterone balance within the body.  

No specific signs or symptoms related to LUFS.

None verified.

Conventional therapy is mainly represented by hormonal therapy that includes administration of specific sex hormones - gonadotropins; hCG (human chorion gonadotropin) or/and hMG (menotropin; human menopausal gonadotropin). hCG is an analogue to LH which naturally induce ovulation so it can be used to trigger the ovulation. hMG maintains low levels of FSH and high levels of LH within post-menopausal women. This state corresponds with similar hormonal balance during natural ovulation and therefore its administration may help to trigger ovulation. 

Hormonal therapy may be substituted or combined with specific drug administration. These medications include clomiphene citrate and letrozole, both up-regulating FSH concentration due to negative feedback on oestrogen levels. Clomiphene citrate inhibits oestrogen receptors in the hypothalamus, inhibiting negative feedback of oestrogen on gonadotropin release, leading to increased FSH levels with consequential maturation of follicle. Letrozole inhibits the conversion of androgens into the oestrogens stimulating the secretion of FSH. 

As there seems to be a relation between hormonal balance, size of follicles and treatment outcomes, the stimulation of FSH inducing the growth of follicle may prove beneficial to a certain level.

Yet there is homonal disturbance causing LUFS, it cannot be connected with any pathological conditions of participating glands that could be solved by surgical intervention.

If conservative medical treatments fail to achieve a full term pregnancy, the physician may suggest the patient undergo in vitro fertilization (IVF). IVF and related assisted reproduction techniques generally start with stimulating the ovaries to increase egg production. After stimulation, the physician surgically extracts one or more eggs from the ovary, and unites them with sperm in a laboratory setting, with the intent of producing one or more embryos. Fertilization takes place outside the body, and the fertilized egg is reinserted into the woman's reproductive tract, in a procedure called embryo transfer. Another option is the hormonal therapy inducing an ovulation which is followed by intrauterine insemination (IUI).

Find more about related issues


Anovulation ―sourced from Wikipedia licensed under CC BY-SA 3.0
Clomifene ―sourced from Wikipedia licensed under CC BY-SA 3.0
Assisted reproductive technology ―sourced from Fertilitypedia licensed under CC BY-SA 4.0
Menotropin ―sourced from Wikipedia licensed under CC BY-SA 3.0
Luteal phase ―sourced from Wikipedia licensed under CC BY-SA 3.0
Endometriosis: A Disease That Remains Enigmatic ―by Acién and Velasco licensed under CC BY 3.0
The role of steroids in follicular growth ―by Drummond licensed under CC BY 2.0
Letrozole ―sourced from Wikipedia licensed under CC BY-SA 3.0
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