Therapy options

This application helps to propose an appropriate fertility therapy method and to find the most suitable clinic worldwide based on the price, duration and legislative options of the treatment in various countries.

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How can Early onset of pubarche affect fertility

Thelarche (onset of breast development) and pubarche represent observable markers of underlying hormones that are dependent on the maturation of unique endocrine axes, i.e., the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axis, respectively. Premature pubarche has been associated with a relative adrenal hyperandrogenism and hyperinsulinemia (high blood level of insulin). Those girls are at higher risk of developing ovarian hyperandrogenism (excess of male sex hormones – androgens), polycystic ovary syndrome and oligomenorrhea (infrequent menstruation) causing ovulatory dysfunction, which can lead to infertility because no eggs are released to be fertilized.

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