The interaction with gene may be a key point of the pathogenesis in PCOS.
Polycystic ovary disease is a one of the leading causes of female infertility. Polycystic ovary syndrome causes more than 75% of cases of anovulatory infertility. An anovulatory cycle is a menstrual cycle during which the ovaries do not release an oocyte. Therefore, ovulation does not take place. If no oocyte is produced, no oocyte may go through fallopian tubes and fertilization cannot happen.
Hyperandrogenism (a medical condition characterized by excessive levels of androgens in the body) and insulin resistance are the metabolic hallmark of PCOS women. There is an increased risk of pregnancy complications in PCOS women. Nowadays a growing body of evidence points to a high prevalence of pregnancy complications in PCOS women. PCOS was strongly associated increased risk of early pregnancy loss, gestational diabetes (GDM), pregnancy-induced hypertension, preterm birth, small for gestational age, large for gestational age, caesarean section and operative vaginal delivery.
It should be noted that there were the close link between PCOS and obesity and the association of obesity with poor pregnancy outcome, so, it might be possible that possible confounding effect of body mass index (BMI) play a role in adverse effect of PCOS on pregnancies.