Both acute and chronic infection can cause partial or complete obstruction of sperm transport (oligozoospermia or azoospermia), and subsequently reduced fertility or male infertility. Chronic inflammatory changes in the seminiferous tubules in orchitis are expected to disrupt the normal process of spermatogenesis (production of sperm) and cause alterations in sperm number and quality. Inflammation may act as a co-factor of infertility. Pressure-induced rupture of the epididymal duct will disrupt the blood–testis barrier, activate an immunological defense reaction, and induce the production of anti-sperm antibodies. It is suggested that 15% of male infertility is related to genital tract infection. The prevalence of MG in male of infertile couples found to be higher than normal.