Physical inactivity are often found to be the principal causes of female infertility. Gametes, embryos and uterus seem to be negatively affected by the abnormal hormonal and metabolic environment present in obese man and women. An overweight man has a higher risk of having abnormal sperm. There is now emerging evidence that male obesity impacts negatively on male reproductive potential not only reducing sperm quality, but in particular altering the physical and molecular structure of germ cells in the testes and ultimately mature sperm. Recent data has shown that male obesity also impairs offspring metabolic and reproductive health suggesting that paternal health cues are transmitted to the next generation with the mediator mostly likely occurring via the sperm.