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This application helps to propose an appropriate fertility therapy method and to find the most suitable clinic worldwide based on the price, duration and legislative options of the treatment in various countries.

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Sperm DNA damage treatments

Self therapy does not exist.

Conventional medicine does not exist.

Assisted reproduction therapy does not exist.

How can Sperm DNA damage affect fertility

In the genital tract, low levels of ROS are necessary for normal function of human spermatozoa, including their 

  • capacitation (is the step in the maturation of mammalian spermatozoa and is required to render them competent to fertilize an oocyte),
  • acrosome reaction (the reaction that occurs in the acrosome of the sperm as it approaches the egg, a sperm must first fuse with the plasma membrane and then penetrate the female egg in order to fertilize it) and
  • sperm-oocyte fusion (a process in which two cells combine in one). 

On the other hand, excessive OS may cause lipoperoxidation of sperm (the oxidative degradation of lipids) membranes resulting in DNA damage and sperm apoptosis(a process of programmed cell death). After gaining entry into the sperm, ROS target genetic materials, destroying mitochondrial DNA and inhibiting intracellular ATP (a nucleoside triphosphate) production. Without proper ATP production, both functionality and sperm motility is affected and fertilization of an egg is not possible.

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